Donepezil and its Use in Alzheimer’s Disease


Donepezil is a drug that was developed by Pfizer and his partner Eisai. In the market, it is known as Aricept and is presently sold as a generic drug by many suppliers. It is an acetylcholinesterase inhibitor that is mainly used as a palliative treatment of Alzheimer’s disease. This drug was the best-selling drug for […]

Cholinesterase Inhibiting Ability of Cymserine


Cymserine is an experimental drug with a potent reversible cholinesterase inhibiting properties, which is currently being investigated for its potential for the treatment of Alzheimer’s disease and some types of dementia. The drug is related to physostigmine, a parasympathomimetic alkaloid that occurs naturally in the Calabar bean that is endemic to Western Africa. Cymserine has […]

Neuroprotective Abilities of Ladostigil


Ladostigil is a cholinesterase enzyme inhibiting compound initially developed as a potential treatment and management for Alzheimer’s disease (AD). The Phase IIb of its trials for the treatment of AD was discontinued in 2012, when it did not meet its primary endpoint. The consensus among experts is that further studies were abandoned when it was […]

The All-Natural Effects of Celastrus Paniculatus

Celastrus paniculatus

Celastrus paniculatus is a climbing liana plant endemic to regions in India that have an elevation of up to 1,800 meters above sea level. Also known as “intellect tree,” Celastrus paniculatus has been used for quite some time in India’s traditional Unani and Ayuverdic medicine to treat stomach disorders and for sluggish memory. The Unani […]

Huperzine A – Naturally Occurring Nootropic


Huperzine A has been touted as one of the world’s best naturally occurring cognitive enhancers. This compound is basically an alkaloid extracted from Huperzia Serrata, a firmoss that is endemic to China. Proponents and marketers of Huperzia A claim that the plant is part of an ancient Chinese remedy for memory loss but evidence to […]