Coluracetam: A Highly Potential Nootropic for Anxiety Disorders


ColuracetamColuracetam is one of the more recent derivatives of piracetam. It naturally caught the attention of nootropic users being yet another drug from the racetam family. The community of nootropic users has been closely observing how studies on coluracetam progresses to see how they can benefit from this new addition to the racetam line of nootropics. Current studies on coluracetam however, are focused mainly on its potential as treatment for anxiety disorders and Alzheimer’s Disease. Coluracetam shares a lot of characteristics with other racetams, with its structure bearing a strong similarity with Pramiracetam.

Developed and registered in Japan as recent as 2005, initial tests on coluracetam show positive results on patients suffering from Major Depressive Disorder (MDD) and General Anxiety Disorder (GAD). Other studies suggest that coluracetam may also be used for the treatment and prevention of optic nerve and retinal injuries.

The initial tests also show that coluracetam has a high bioavailability, with the substance reaching the brain of lab rats within 30 minutes after oral administration. This quality however, may be tempered a bit by the fact that the same study shows that coluracetam has a short half-life of only three hours after oral administration.

The action of coluracetam is distinct from other racetams in the sense that it makes the high affinity choline uptake (HACU) function of the brain much more efficient. HACU is the process in the brain wherein choline is synthesized into acetylcholine, an essential and powerful neurotransmitter responsible for memory retention, logical reasoning, and other cognitive processes in the brain. This is also the same reason why coluracetam is also anticipated to be developed as a cure for Alzheimer’s Disease where the HACU is impaired.

Despite being new in the nootropic scene, it is estimated that users of coluracetam in the US already number in the thousands. While reports on the effects of coluracetam from these users can not be regarded as conclusive, there are indications that this drug has a profound effect in improving memory retention and recall. Since its structure is akin to pramiracetam, some users report a heightened sensory perception. Other reported benefits from users include the increased ability to learn and learn quickly, sharpened focus, and improved verbal fluency.

Those who are planning to try coluracetam supplementation should keep in mind however, that there is very little data available about the effects of this drug on the body. There is also the question of availability as sources of coluracetam are very scarce. Based on reports from users, coluracetam apparently shares similar side-effects with other potent racetams like headaches, dizziness, nausea, light-headedness, and depression.


  • It is potent.
  • It show promise as a mainstream medicine.
  • It has a high bioavailability.
  • Results are long lasting.


  • Data about its prolonged use is scarce.
  • It has very limited availability.
  • It has a short half-life.
  • It has the same side-effects as other powerful racetams.

Due to insufficient data, the proper dosage for coluracetam supplementation has not yet been firmly established. Based on data from testing with lab rats, experienced nootropic users can benefit from a daily dose of 200mg. Those who are new to using racetams may be able to benefit from doses as low as 20mg. Most users of coluracetam either take the drug orally or through sublingual administration. Although toxicity levels of coluracetam for humans hasn’t been established, this drug has been generally regarded as safe even in high doses.

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