Galantamine as a Treatment for Mental Impairment


Galantamine is perhaps best known these days as an FDA approved drug for the treatment of Alzheimer’s disease. As a nootropic supplement, galantamine is one of the few cognitive enhancement aids that are being marketed as being all-natural. This marketing claim may be true as galantamine is an alkaloid extracted from the bulbs and flowers of the Galanthus Caucasicus plant. However, it can also be produced synthetically. Galantamine can be used as a standalone nootropic, but experienced nootropic users usually stack it with other cognitive enhancers in order to maximize the effect of the primary nootropic in the stack.

The study into the properties of galantamine as a treatment for mental impairment was spurred by traditional medicine where the Galanthus Caucasicus plant used as an energy tonic to counteract mental lethargy. Initial studies began in the former Soviet Union in 1950s where galantamine was first extracted. Towards the end of the 1950s extraction of galantamine in an industrial scale was developed in Bulgaria. It has since been medically prescribed in Eastern Europe for various ailments and conditions involving the central nervous system.

It is believed that the nootropic effects of galantamine come from its ability to inhibit the production of enzymes that destroys acetylcholine, an essential neurotransmitter responsible for most of the cognitive processes in the brain. As more of this neurotransmitter in the brain is preserved, the cognitive processes in the brain such as memory retention, focus, and logical reasoning is enhanced.

GALANTAMINEGalantamine is seldom taken on its own as a nootropic by experienced users. It is often regarded as “helper” to maximize the effects of the main nootropic taken by the user. This is also true even for inexperienced users of nootropics. As an inhibitor of enzymes that degrades the acetylcholine neurotransmitter, users of nootropics often stack it with Alpha GPC or choline bitartrate as these two compounds are thought to facilitate the formation of acetylcholine in the brain.

The reported positive effects of galantamine as a nootropic include better memory retention and recall, improved focus and concentration, increased learning ability, and a heightened sensory perception. Unlike other nootropics, galantamine appears to have a positive effect on sleep patterns, with some users reporting of a very deep sleep that are sometimes accompanied by lucid dreaming.  Galantamine users report being able fall asleep easier and waking up feeling refreshed.

An upset stomach is one of the more common complaints of users who supplement with galantamine along with other negative effects such as fatigue, dizziness, loss of appetite, and allergy. Improper supplementation with galantamine is also believed to cause what is commonly referred to as a brain fog in the nootropic community.


  1. All natural
  2. May complement other nootropic agents
  3. Widely available as either a prescription drug or as a dietary supplement
  4. It can regulate sleep patterns


  1. May not be potent when taken nootropic on its own
  2. May contribute to the onset of brain fog
  3. It has unpleasant negative effects
  4. May not be ideal for people allergic to daffodils

The daily dose of galantamine supplementation is set at 4 to 24mg a day. This dosage may change depending on the stack of nootropics being taken. Galantamine is also popular among proponents of lucid dreaming and out-of-body enthusiasts, as supplementing with it is believed to make such events more intense.

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