Indeloxazine: Mechanism of Action, Benefits, Side Effects and Dosage


Indeloxazine has been medically used in Japan since the year 1988 to treat the cerebrovascular disease. It is potentially a nootropic, and it seemingly produces its nootropic influences through a litany of biochemical processes. This drug was primarily created as a pharmaceutical drug by the Yamanouchi Pharmaceutical Co., Ltd in the 1980s like we have already said. It was approved to be utilized in cerebral activation as well as neuroprotection after undergoing several pre-clinical, as well as human clinical tests in Korea and Japan.

How does Indeloxazine work?

When the potential antidepressant activities of indeloxazine hydrochloride were studied, a lot of interesting facts came up. It was discovered that this drug was responsible for increasing the extracellular amounts of both norepinephrine and serotonin in the frontal cortex of rats that were freely moving. Further studies revealed that indeloxazine inhibits the uptakes of both norepinephrine and serotonin which may accord it its antidepressant property. In addition, the increased serotonin release that is induced by this drug may add to its powerful effects on the serotonergic system in the body.

Does it have benefits?

Indeloxazine neuroprotective influencesIndeloxazine has been shown to possess antidepressant, anticonvulsant, nootropic and neuroprotective influences. Indeloxazine has been shown to possess protective effects on patients with ischemia. This may be partly attributed to the fact that this drug improves the metabolism of the cerebral energy. A study was conducted which duly vindicated the above theory. In addition, this drug has also been shown to have positive effects on the learning process. Research has shown that those people who use indolexazine reveal a marked increase in their learning capacity. Indolexazine also has an antidepressant effect. This is probably due to its mechanism of action that has shown it to be a non-competitive NMDA antagonist just like ketamine. This makes it have a very fast lift of mood as has been reported by users.

Further, indeloxazine also enhances the release of acetylcholine. It does this through indirectly activating the 5-HT 4 receptor. Acetylcholine is a very important neurotransmitter in the body which is responsible for enhancing the attention, increasing arousal as well as plasticity (which is an essential basis for both learning and memory). Therefore, since the drug indeloxazine causes increase in this neurotransmitter it follows that it positively influences learning and memory too.

The side Effects

Indeloxazine has the potential of being a teratogen. It, therefore, should not be used by pregnant women or by women who are in the process of becoming pregnant. The drug possesses effects that are mediated via the monoaminergic neurotransmitter systems such as inhibitors of norepinephrine reuptake and inhibitors of selective serotonin reuptake. It is, therefore, inadvisable to mix it with other supplements or medication that act together with norepinephrine or serotonin. The list of such supplements and medications include: prescription antidepressants, stimulants or ADH medications, OTC stimulants, serotonergic supplements including L-Tryptophan, and 5-HTP.


The information about the dosage for this drug is limited. However, there is a research that was done, and they were using 10-20mg per day. It was administered once per day to the ninth day after acquisition an injury. The result was a significant improvement in the performance of passive impairment. This is the dosage that you should probably use. However, we know that with nootropics, you have to tweak the dosages to find the one that suits your body. So if you want to use it for its nootropic value, you will have to find the right dosage for you which I believe is around the aforementioned value.

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