Medical Applications of N-Acetyl L-Tyrosine


An n-acetyl l-tyrosine supplement is basically an acetylated form of the l amino acid, l-tyrosine. Supplementation with l-tyrosine is primarily aimed at raising the stores of dopamine and norepinephrine in the body. As with any other acetylated supplements, its manufacturers claim that adding n-acetyl increases the compound’s bioavility.

L-tyrosine is one of the 22 amino acids needed for protein synthesis. This makes it a common addition in muscle building and performance enhancing supplements. Apart from being a muscle builder however, l-tyrosine has a variety of other medical and supplemental applications. This amino acid has been used to treat a variety of medical conditions, as weight loss aid, and even as components of topical creams.

n-acetylCategorized as a non-essential amino acid, the body can synthesize its own stores of l-tyrosine. It can also be sourced from amino acid rich foods such as meat, dairy products, eggs, fish, nuts, and wheat. L-tyrosine is essential in the synthesis of dopamine, an important plasma neurotransmitter in the brain. Dopamine is also referred to as the “feel good” compound in the brain and high levels of it gives one a feeling of extreme relaxation, contentment, and motivation.

This effect of dopamine is regarded by some as its main nootropic effect and since l-tyrosine helps in activating the synthesis of dopamine, l-tyrosine can be considered as a nootropic agent. Dopamine can also transform into norepinephrine, which is another neurotransmitter. Norepinephrine gives one the ability to resist extreme stress from an external aggressor. This means that l-tyrosine can also make you more resistant to stress and anxiety.

There are some studies supporting the claims that formulating amino acids with acetyls makes it more bioavailable. If this were really the same with l-tyrosine, then it should follow that its acetylated form should be absorbed more quickly into the system and into the blood-brain barrier. Once it gets crosses the blood-brain barrier, it can start doing what it does best and make you feel better and more relaxed.

The absence of stress makes one function better and for the brain’s processes to function more smoothly. In essence, this should be the cognitive enhancement ability of l-tyrosine. In theory, taking n-acetyl l-tyrosine should help one achieve this effect much faster. This ability also makes n-acetyl l-tyrosine an appealing addition to a nootropic stack. Some users claim to experience a general feeling of well-being, which makes them highly motivated to study some more or get some work done.

There are those who tried supplementing with the amino acid however, who say that there hardly was any noticeable nootropic effect from it. While these users admit that it helps them feel more relaxed, it also disturbs their sleep patterns at the same time, which almost negates its effect immediately the day after. Some of its other side effects include diarrhea, bloated feeling in the stomach, dizziness, headaches, and nausea.


  • Cheap.
  • Widely available.
  • Works faster than plain l-tyrosine.
  • Contributes to the synthesis of dopamine.
  • It makes for a good addition to nootropic stacks.


  • May not work for everyone.
  • Has no direct effect on the cognitive processes.
  •  May have negligible effects when taken all by itself.
  • It has unpleasant side effects.

Since n-acetyl l-tyrosine is more bioavailable than l-tyrosine, it can be taken in smaller dosages. You can start supplementing with n-acetyl l-tyrosine at 150mg and work your way up from there to determine what dose will work best for you. As with any other supplements, it will be a good idea to consult with a medical professional before adding l-tyrosine to your daily supplements.



Speak Your Mind