Pramiracetam – A Highly Effective Cholinergic Racetam

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Pramiracetam is a fat-soluble compound derivative of the nootropic drug, Piracetam. It is used as a cognitive enhancer and is estimated to be around 15 to 30 times more potent than Aniracetam, another Piracetam derivative. The mechanism of action of Pramiracetam is not yet fully understood but it is theorized that its actions may be cholinergic in nature and it was observed to influence high affinity choline uptake (HACU).

As a cognitive enhancer, there are studies, albeit limited, that suggest that Pramiracetam can help in creating long-term memory. It is because of this observation that its actions are believed to affect the synthesis or actions of acetylcholine, a type of neurotransmitter in the brain believed to be responsible for the formation of both short-term and long term memory, as well as other cognitive processes.

Pramiracetam was first developed in Belgium in the late 1970s by Parke-Davies, the oldest US drug developer and manufacturer. Patents of the drug were granted in 1978 in Belgium and the US in the following year. Although it was during this same period when Pramiracetam was first observed to have cognitive enhancing properties, it wasn’t until 1984 when it was synthesized specifically for the purpose of being a memory aid and an anti-amnesiac. The drug is currently being sold under the brand names Remen, Pramistar, and Neupramir.

PramiracetamAccording to those who use Pramiracetam as a study or a work aid, it is best taken between 1 to 2 hours before cognitive testing. It must be noted however, that Pramiracetam also has a sedating effect, so unlike some cognitive enhancers that actually promote wakefulness, this racetam might actually induce sleep.

Despite being approved to be released for public use for quite some time now, there is still very little data about its effects, not to mention its exact mechanism of action. The studies on Pramiracetam that focus on memory and cognition are uncontrolled and are just observational. Given the time in which Pramiracetam has been approved for public use, the experiences of the individuals who have become familiar with its effects may be regarded as conclusive, especially if the reported effects are similar.

Those who have tried or are regularly supplementing with Pramiracetam have generally experienced positive results, especially in the area of memory formation and ease of recall. Some report an enhanced mental clarity and an increased focus. It is unclear whether or not Pramiracetam affects learning abilities and logical skills, but some report of being able to communicate better and have better self-confidence. Pramiracetam is still being observed for its potential as a cure for Alzheimer’s disease and other neurological impairment because it was also observed to have neuroprotective abilities.

While Pramiracetam is well-tolerated, it does have a few adverse effects. The most notable of these perhaps is its sedating effect, which is unusual for a piracetam derivative that often have the opposite effect. Depending on your tolerance for pain, a good number of users have also complained of experiencing mild to intense headaches. Other reported Pramiracetam side effects include upset stomach, dizziness, and dry mouth.

PROS

  1. It appears to be an effective cognitive enhancer.
  2. It is estimated to be 15 to 30 times more powerful than piracetam.
  3. It is a good study aid.
  4. It has been observed to have neuroprotective abilities.

CONS

  1. It is a bit on the pricey side.
  2. It has a sedating effect, which is unusual for a racetam.
  3. It has a relatively short half-life of 4 to 6 hours or even less.
  4. It has some unpleasant side effects.

The recommended dosage of Pramiracetam for cognitive enhancement is set at 300 to 400mg divided into several doses daily. Due to its potency, Pramiracetam is not advised for individuals who have little to no previous experience with nootropics. If you are planning of trying out Pramiracetam, it will be best to first consult your doctors about your plan.

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